In cells with the gene silenced which were then subjected to ionizing radiation, 80 % of cells acquired chromosomal aberrations. ‘We also discovered that BRIT1 expression is certainly aberrant in a number of forms of human cancers,’ Lin said. The group found decreased expression of the gene in 35 of 87 instances of advanced epithelial ovarian cancer tumor. They also found decreased expression in breasts and prostate cancer cells compared with noncancerous cells.At March 31, 2014, the business had a complete of $85,758,000 in money, equivalents and marketable securities. Operational Update Enrollment is normally proceeding in the Stage 3 METIV-HCC trial of tivantinib in hepatocellular carcinoma executed by ArQule and its partner, Daiichi Sankyo Co., in the U.S. And Europe; Kyowa Hakko Kirin, the Organization's partner in Asian territories, in February initiated the Phase 3 JET-HCC trial of tivantinib in HCC in Japan, 2014; Patient enrollment is definitely continuing in a number of NIH-sponsored trials with tivantinib, including Stage 2 randomized trials in prostate cancer, head and neck cancer, and kidney cancer; The dose escalation portions of Phase 1 trials with the Firm's proprietary compounds, ARQ 092 and ARQ 087, are nearing completion.