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Clinical trial new era in treatment of neurodegererative disorders signals No serious adverse effects appear from central nervous program infusion of medication that blocks mutated protein The initial clinical trial of a novel approach to treating amyotrophic lateral sclerosis – blocking creation of a mutant protein that causes an inherited form of the progressive neurodegererative disease – may be an initial step towards a new era in the treating such disorders. Investigators from Massachusetts General Medical center and Washington University School of Medicine report that infusion of an antisense oligonucleotide against SOD1, the 1st gene to be associated with familial ALS, had no serious undesireable effects and the medication was effectively distributed thoughout the central nervous system.