When you have been diagnosed, deal strength and perseverance. Below are some suggestions that would help in dealing with the diagnosis – 1 – Try to become familiar with the reality regarding the diagnosis just like the cancer type, whether it offers spread, the treatments obtainable, the side effects, and avoidance after the treatment, treatment schedules, and the genetic viability of the malignancy. 2 – Do not hesitate to talk to your doctor and your loved ones. Inform them that you are ready to encounter and conquer it and they should be extremely frank about the progress the procedure and the malignancy is making.The more surprising findings were that specific treatments appeared to be related to leukemic transformation also. Usage of ESAs or danazol were linked to later advancement of leukemia, independent of the blast or platelet levels. Ayalew Tefferi, M.D., principal investigator of the scholarly study, and a Mayo Clinic hematologist, cautions that the existing findings are based on retrospective observation and need to be validated in correctly designed prospective studies. Tefferi. The scholarly research evaluated the information of 311 Mayo Clinic patients, seen with principal myelofibrosis between 1976 and 2006. Of the patients, at an average follow-up of 27 months, 27 cases of leukemic transformation were documented. Other factors appeared to contribute to the advancement of leukemia, including anemia, leukocytosis and peripheral blood monocyte count greater than or add up to 1×109/L , hypercatabolic symptoms , a splenectomy and treatment with androgens .